Beilstein J. Org. Chem.2018,14, 11–24, doi:10.3762/bjoc.14.2
, oligosaccharides usually bind lectins in a multivalent cooperative fashion. This avidity is significantly greater than the sum of the individual monomeric carbohydrate–protein interactions, and is sometimes referred to as the ‘clusterglycoside’ effect [6]. In order to study biological processes that involve these
PDF
Graphical Abstract
Figure 1:
The three major methods for the synthesis of GAuNPs. (a) Direct reduction of an Au3+ salt in the pr...
Beilstein J. Org. Chem.2014,10, 1672–1680, doi:10.3762/bjoc.10.175
. Furthermore, we confirmed that in case of this specific lectin binding the presentation of lactose units on a cone calixarene is highly preferred with respect to its isomeric form in the 1,3-alternate structure.
Keywords: glycocalixarenes; clusterglycosideeffect; multivalency; click chemistry; surface
PDF
Graphical Abstract
Figure 1:
Lactosylthioureidocalix[4]arenes I–III used to inhibit Gal-3 [20,21].